An aggressive, usually diffuse non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.
Symptoms of Mantle Cell Lymphoma
The following features are indicative of Mantle Cell Lymphoma:
swollen lymph nodes
fever
night sweats
weight loss
fatigue
gastrointestinal obstruction
multiple intestinal polyps
high white blood cell count
anorexia
It is possible that Mantle Cell Lymphoma shows no physical symptoms and still is present in a patient.
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Common Causes of Mantle Cell Lymphoma
The following are the most common causes of Mantle Cell Lymphoma:
somatic DNA damage
Risk Factors for Mantle Cell Lymphoma
The following factors may increase the likelihood of Mantle Cell Lymphoma:
older age
being male
White race
autoimmune conditions
being on immune suppressing medications
HIV/AIDS
HTLV-1
Epstein-Barr virus
helicobacter pylori infection
Prevention of Mantle Cell Lymphoma
Yes, it may be possible to prevent Mantle Cell Lymphoma. Prevention may be possible by doing the following:
maintain a healthy immune system
maintain a healthy weight
eat a healthy diet
Occurrence of Mantle Cell Lymphoma
Number of Cases
The following are the number of Mantle Cell Lymphoma cases seen each year worldwide:
Very rare between 1K - 10K cases
Common Age Group
Mantle Cell Lymphoma most commonly occurs in the following age group:
Aged > 50 years
Common Gender
Mantle Cell Lymphoma can occur in any gender.
Lab Tests and Procedures for Diagnosis of Mantle Cell Lymphoma
The following lab tests and procedures are used to detect Mantle Cell Lymphoma:
Physical exam: To diagnose for mantle cell lymphoma
Flow cytometry test: To diagnose for mantle cell lymphoma
Bone marrow aspiration: To diagnose for mantle cell lymphoma
Biopsy: To diagnose for mantle cell lymphoma
Doctor for Diagnosis of Mantle Cell Lymphoma
Patients should visit the following specialists if they have symptoms of Mantle Cell Lymphoma:
Hematologist
Oncologist
Complications of Mantle Cell Lymphoma if untreated
Yes, Mantle Cell Lymphoma causes complications if it is not treated. Below is the list of complications and problems that may arise if Mantle Cell Lymphoma is left untreated:
bone marrow
bone and neurologic lesions
Procedures for Treatment of Mantle Cell Lymphoma
The following procedures are used to treat Mantle Cell Lymphoma:
Chemotherapy: Helps to kill cancerous cells
Immunotherapy: Helps in treating the condition
Hematopoietic stem cell transplantation: Helps in treating the condition
Self-care for Mantle Cell Lymphoma
The following self-care actions or lifestyle changes may help in the treatment or management of Mantle Cell Lymphoma:
Exercise: To reduce or prevent lymphoma
Quit smoking: Avoid the use of tobacco
Alternative Medicine for Treatment of Mantle Cell Lymphoma
The following alternate medicine and therapies are known to help in the treatment or management of Mantle Cell Lymphoma:
Massage therapy: Relax muscles and alleviate body pain
Meditation: To ease the side effects of medicines
Relaxation exercises: Helps reducing stress
Patient Support for Treatment of Mantle Cell Lymphoma
The following actions may help Mantle Cell Lymphoma patients:
Join online support groups: Provides support to patients and their families living with Mantle cell lymphoma
Last updated date
This page was last updated on 2/04/2019.
This page provides information for Mantle Cell Lymphoma.